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'Revolutionary' NMR Advance

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CAMBRIDGE, Mass., May 21, 2007 -- A highly sensitive nuclear magnetic resonance (NMR) approach to detecting the molecular structure of tiny proteins reduces the size of the samples needed so much it might one day diagnose glaucoma from a single teardrop. Currently, NMR requires an SUV-sized, million-dollar machine and protein samples so large it can take months to gather enough material. The new technique, developed by researchers from the Massachusetts Institute of Technology's Center for Bits and Atoms, decreases by several orders of magnitude the amount of protein needed to measure molecular structure and uses a...Read full article

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    Published: May 2007
    Glossary
    electrophoresis
    The movement of particles or ions in a solution toward the electrode having the opposite sign because of the application of an electrical field.
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    nuclear magnetic resonance
    A phenomenon, exploited for medical imaging, in which the nuclei of material placed in a strong magnetic field will absorb radio waves supplied by a transmitter at particular frequencies. The energy of the radio-frequency photons is used to promote the nucleus from a low-energy state, in which the nuclear spin is aligned parallel to the strong magnetic field, to a higher-energy state in which the spin is opposed to the field. When the source of the radio waves is turned off, many nuclei will...
    photonics
    The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
    probe
    Acronym for profile resolution obtained by excitation. In its simplest form, probe involves the overlap of two counter-propagating laser pulses of appropriate wavelength, such that one pulse selectively populates a given excited state of the species of interest while the other measures the increase in absorption due to the increase in the degree of excitation.
    spectrometer
    A kind of spectrograph in which some form of detector, other than a photographic film, is used to measure the distribution of radiation in a particular wavelength region.
    x-ray crystallography
    The study of the arrangement of atoms in a crystal by means of x-rays.
    biomedicalBiophotonicsCenter for Bits and AtomscoilCommunicationsdrug discoveryelectrophoresisFrancis CrickGershenfeldMITmolecularnanoNews & FeaturesNMRnuclear magnetic resonancephotonicsprobeproteinSensors & DetectorsShuguang ZhangSpectrometerspectroscopytabletopx-ray crystallography

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