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Lab Use of Qdots Specified

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ATLANTA, May 29, 2007 -- In a step toward earlier disease diagnosis and personalized medicine, detailed protocols have been developed for using bioconjugated quantum dots -- luminescent nanoparticles linked to biological molecules -- to track biomarkers in cells and tissues. Using prostate cancer specimens, researchers at Emory University and the Georgia Institute of Technology have confirmed that bioconjugated quantum dots (qdots) are effective in simultaneously identifying multiple molecular biomarkers in cancer tissue. The qdots have shown great promise as tools for disease diagnosis and treatment, but until...Read full article

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    Published: May 2007
    Glossary
    biomarker
    A biomarker, short for biological marker, refers to a measurable and quantifiable indicator of a biological condition, process, or response. Biomarkers can be substances or characteristics that are objectively measured and evaluated as an indicator of normal biological processes, pathogenic processes, or pharmacological responses to therapeutic interventions. These markers are often used in medical and scientific contexts to assess health status, diagnose diseases, monitor treatment outcomes,...
    immunohistochemistry
    Immunohistochemistry (IHC) is a method for detecting antigens or haptens in cells of a tissue section by using labeled antibodies to bind specifically to their antigens. IHC is used for disease diagnosis, biological research and in drug development. Using IHC visualized tumor markers such as enzymes, oncogenes and tumor-specific antigens, physicians can diagnose if a tumor is benign or malignant and determine the stage and grade of a cancer.
    multiplexing
    The combination of two or more signals for transmission along a single wire, path or carrier. In most optical communication systems this is referred to as wavelength division multiplexing, in which the combination of different signals for transmission are imbedded in multiple wavelengths over a single optical channel. The optical channel is a fiber optic cable or any other standard optical waveguide.
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    nanoparticle
    A small object that behaves as a whole unit or entity in terms of it's transport and it's properties, as opposed to an individual molecule which on it's own is not considered a nanoparticle.. Nanoparticles range between 100 and 2500 nanometers in diameter.
    photonics
    The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
    Basic Sciencebioconjugated quantum dotsbiologicalbiomarkerbiomedicalBiophotonicscadmiumCommunicationsdisease diagnosisfluorescentGeorgia TechimmunohistochemistrymedicinemoleculemultiplexingnanonanoparticleNews & FeaturesNiephotonicsqdottherapeutictissueWang

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