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Iron crystals may play a role in neurodegenerative diseases

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Nancy D. Lamontagne

Although iron is necessary for some cellular functions, it also can cause damage in certain forms. For example, iron deposits in the brain may contribute to neurodegenerative diseases such as Parkinson’s, Huntington’s and Alzheimer’s. Optical microscopy has revealed that iron-loaded transferrin tends to aggregate. Images reprinted with permission from Angewandte Chemie. The iron ions (Fe3+) present in the body always must be enclosed so that they do not cause damage. In blood plasma, iron is carried by the transport protein transferrin. An ion binds to the protein in a way that shields...Read full article

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    Published: April 2008
    AlzheimersBasic ScienceBiophotonicsHuntington’sironMicroscopyneurodegenerative diseasesParkinson’sPostscripts

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