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Deposition Sciences Inc. - Difficult Coatings - LB - 8/23

Finding the proverbial needle

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Novel cross-linker helps to identify peptides and thus to characterize protein structures.

Gary Boas

Investigators working in the field of proteomics are interested in studying the three-dimensional structures of proteins and the covalent connections in protein-protein complexes so that they can map the contact points when the proteins are folded, for example. Chemical cross-linking coupled with mass spectrometric analysis often is used to access this information. Researchers have reported a novel IR Chromogenic cross-linker (IRCX) that enables them to distinguish between cross-linked and noncross-linked peptides, thus facilitating study of the three-dimensional structures of proteins....Read full article

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    Published: August 2008
    Basic ScienceBiophotonicsmass spectrometric analysispeptidesproteomicsResearch & Technologyspectroscopy

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