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Hamamatsu Corp. - Earth Innovations LB 2/24

Nanosensors probe pH in cells

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Hank Hogan

By exploiting surface-enhanced Raman scattering, scientists from Harvard University Medical School in Boston and from the Institute for Molecular Biology and Bioinformatics in Berlin have shown that gold and silver nanoaggregates can probe the pH of live cells in microscopic detail. They also demonstrated that a two-photon approach can extend the technique to a wider pH range. These methods could allow a better understanding of the trafficking, recycling and recruitment of intra- and extracellular molecules, report the researchers. Surface-enhanced Raman scattering provides information on...Read full article

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    Published: December 2007
    Glossary
    surface-enhanced raman scattering
    Surface-enhanced Raman scattering (SERS) is a powerful analytical technique that enhances the Raman scattering signal of molecules adsorbed on or near certain nanostructured surfaces. Raman scattering is a process in which light interacts with molecular vibrations, providing a fingerprint-like spectrum that can be used to identify and characterize chemical compounds. SERS significantly amplifies the Raman signal, making it more sensitive and allowing for the detection of molecules at very low...
    Biophotonicsmolecular biologyResearch & TechnologyscientistsSensors & Detectorssurface-enhanced Raman scattering

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