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Keeping it together (or not) with molecular glue

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Gary Boas

Spontaneous hybridization of complementary DNA drives a range of biological functions and can be exploited to build DNA-based materials and nanoarchitectures. Researchers, therefore, have devoted considerable time and effort to controlling hybridization. In recent years, a team with Osaka University in Ibaraki, Japan, has developed a series of synthetic small molecules — called mismatch binding ligands — that bind to two DNA strands that do not hybridize with one another spontaneously, thereby inducing hybridization. They recently reported a photoswitchable molecular glue that enables...Read full article

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    Published: November 2007
    biologicalBiophotonicsDNANews & FeaturesspectroscopySpontaneous hybridization

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