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Turning microscopes into nanoscopes

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A new dye could provide a resolution of 10 nm without being confined to thin samples

Hank Hogan

The diffraction limit isn’t the barrier it used to be. Researchers around the world have developed schemes that allow optical imaging far below the traditional diffraction limit of half a wavelength of light. Many of these techniques, however, can be used only on thin samples. Now researchers at the Max Planck Institute for Biophysical Chemistry in Göttingen, Germany, have come up with a new dye, 5-NHSS, and an associated technique that overcome this problem. The method promises far-field optical microscopy with a resolution of 10 nm. Because it can be done using multiphoton excitation, it...Read full article

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    Published: October 2007
    Basic ScienceBiophotonicsMicroscopyResearch & Technology

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