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Hamamatsu Corp. - Earth Innovations LB 2/24

Mirror slides enhance fluorescence signal

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David Shenkenberg

Standard fluorophores do not luminesce brightly enough for some applications. Instead of improving fluorophores, researchers in France have developed metal-coated microscope slides that behave like a mirror. The slides reflect fluorescence toward a microscope’s objective lens and significantly boost the fluorescence signal. The researchers set out to develop the mirror coating for nanometer-scale applications such as building biosensors, particularly for labeling DNA biochips. However, they suspected that the coating might improve the fluorescence signal on a microscopic scale as well. So...Read full article

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    Published: February 2007
    Glossary
    microscope
    An instrument consisting essentially of a tube 160 mm long, with an objective lens at the distant end and an eyepiece at the near end. The objective forms a real aerial image of the object in the focal plane of the eyepiece where it is observed by the eye. The overall magnifying power is equal to the linear magnification of the objective multiplied by the magnifying power of the eyepiece. The eyepiece can be replaced by a film to photograph the primary image, or a positive or negative relay...
    Biophotonicsfluorescence signalmicroscopeMicroscopyMirror slidesNews & FeaturesSensors & Detectors

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