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‘Superlens’ microscope gets inside the nucleus

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Gary Boas

Humans and other higher organisms have evolved complex mechanisms for detecting and repairing the chromosome breaks caused by either exposure to genotoxic agents or inherent metabolic processes. This DNA damage signaling and repair involves a highly coordinated series of molecular events, and defects in many of these have been tied to increased risks of cancer as well as to developmental and immunologic abnormalities. Using immunofluorescence methods, researchers have gained significant in-sight into the positioning of signaling and repair proteins and the ways in which the proteins...Read full article

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    Published: January 2007
    BiophotonicschromosomeDNAMicroscopyorganismsResearch & Technology

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