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Fluorescent nickel sensor could yield health benefits

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Hank Hogan, [email protected]

Too much nickel could make life not worth a plugged nickel because an excess of the metal can adversely affect the respiratory and immune systems. Just how much is too much is a bit of an unknown, however, and it also is somewhat unclear as to how best to treat a nickel overdose. Now a group of researchers from the University of California, Berkeley, has demonstrated a turn-on fluorescent sensor for detecting nickel in living cells. It could prove useful in studying the cellular regulation and role of the metal, information that associate chemistry professor Christopher J. Chang said is...Read full article

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    Published: March 2010
    Glossary
    spectrofluorometer
    An automatic scanning instrument that is used to study a substance's fluorescence over a wide range of wavelengths. It consists of a radiation source, a grating that functions as the monochromator in selecting the exciting radiation, a second grating that serves as the emission monochromator, and a photoelectric device that is used to detect the emissions.
    spectrophotometer
    A spectrophotometer is a scientific instrument used to measure the intensity of light at various wavelengths in the electromagnetic spectrum, typically in the visible and ultraviolet regions. It is commonly employed in various fields such as chemistry, physics, biology, and environmental science for a wide range of applications, including chemical analysis, color measurement, and concentration determination of substances in a solution. Spectrophotometers operate by passing a beam of light...
    Basic ScienceBiophotonicsBioScanBodipyboron-dipyrrometheneCaliforniacellsChristopher J. Changfluorescent dyefluorescent sensorHank HoganImagingimmune systemJournal of the American Chemical Societylaser scanning microscopelive-cell imagingmetal chelationMicroscopyNewsnickelnickel cationNS1Photon Technologyreceptorrespiratory systemSensors & DetectorsspectrofluorometerspectrophotometerTest & MeasurementUniversity of California BerkeleyVarianZeiss

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