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Building a better protein killer

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Scientists at The Scripps Research Institute have reported a light-activated “warhead” molecule that, when tethered to protein-binding small molecules, greatly increases their ability to inactivate target proteins. Using this molecule with chromophore-assisted light inactivation – or CALI – could contribute to the development of research tools that could advance cancer treatments and other therapies. The warhead came about because the researchers wanted to assemble a large collection of specific, potent antagonists for proteins. “Our screening methodology is...Read full article

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    Published: May 2010
    Basic ScienceBiophotonicsBioScanBoasCALIchromophore-assisted light inactivationenergyGaryGary BoasNature Chemical BiologyNewsphoto-activated protein inhibitorsScripps Research Institute

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