The spring 2006 issue of the quarterly review Affymetrix Microarray Bulletin focuses on advances in cancer research. Published by !%Affymetrix Inc.%!, the downloadable 27-page document features an article on how technologies such as siRNA and exon arrays, and tissue and genotyping microarrays were used to create a diagnostic signature for rhabdomyosarcoma, a childhood cancer. It includes a work-flow diagram on the diagnosis and prognosis of sarcomas using gene expression and DNA polymorphism profiling. The use of gene expression profiles to select the best chemotherapy regimens for individual breast cancer patients is discussed in another article.