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Defocusing improves microscopic analysis of red blood cells

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Gary Boas

Several years ago, Oscar N. Mesquita, a researcher with the Federal University of Minas Gerais in Belo Horizonte, Brazil, was measuring the movement of macrophages. At one point, he looked into the microscope before focusing and noticed that some of the otherwise transparent parts of the macrophages were visible. Not knowing exactly what he was seeing, he searched the optical theory literature for some reference to “defocused microscope.” Unfortunately, he found that — although it was a known phenomenon — the problem had not been solved. Mesquita and his...Read full article

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    Published: June 2006
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