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Laser microscopy reveals gene splicing

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Compiled by BioPhotonics staff

A new laser-based microscopy method allows scientists to decipher basic biology and understand how diseases related to cellular micromachines occur. The microscope, developed at Brandeis University, uses lasers to study the splicing of pre-messenger RNA molecules, an essential process in creating proteins to sustain advanced organisms such as humans. The splicing process is carried out by cellular micromachines called spliceosomes. By understanding how the process works, the researchers hope to find therapies that fix the splicing process in cases where it does not work properly. Their...Read full article

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    Published: May 2011
    Glossary
    microscope
    An instrument consisting essentially of a tube 160 mm long, with an objective lens at the distant end and an eyepiece at the near end. The objective forms a real aerial image of the object in the focal plane of the eyepiece where it is observed by the eye. The overall magnifying power is equal to the linear magnification of the objective multiplied by the magnifying power of the eyepiece. The eyepiece can be replaced by a film to photograph the primary image, or a positive or negative relay...
    AmericasBiophotonicsBioScanBrandeis Universitycellular micro-machinesColumbia Universityexonsfluorescent dyesgenomic DNAintronsLight SourcesMassachusettsmicroscopeMicroscopyNewspre-messenger RNA moleculesproteinsRNARNA transcriptionsingle protein moleculesspecialized light microscopespliceosomessplicingtagged molecules splicing processUniversity of Massachusetts Medical SchoolLasers

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