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NIH Grants $12.5M for Optogenetics, Imaging, Tumor Detection

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PHILADELPHIA, Oct. 6, 2011 — Three labs at the University of Pennsylvania have received $12.5 million from the National Institutes of Health (NIH) to pursue light-driven ideas expected to advance medical research. These awards are granted under the NIH’s Pioneer, New Innovator and Transformative Research Projects awards as part of the organization’s $143.8 million national grant program. Researchers at the University of Pennsylvania have received a grant to explore optogenetic techniques to restore light sensitivity to afflicted retinas. (Image: W. Tang, Bennett laboratory, Perelman School of...Read full article

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    Published: October 2011
    Glossary
    blindness
    The inability to perceive visual images (visible radiant energy). In human beings, blindness is defined as a visual acuity of less than one-tenth normal vision.
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    Albert M. MaguireAmericasArjun RajBiophotonicsblindnessCancer CellsEmory UniversityF.M. Kirby Center for Molecular Ophthalmologyfluorescent nanoparticlesgene therapyGeorgiaGeorgia TechImagingJean BennettLuk Vandenberghemedical researchmicroscopy techniquesNational Institutes of HealthNew Innovator AwardsNIH grantsoptogeneticsPennsylvaniaPerelman School of MedicinePioneer AwardsResearch & Technologyretinal disordersSensors & DetectorsSunil SinghalTransformative Research Projects awardstumor boundariesUniversity of Pennsylvania

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