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Single-Neuron Observations Reveal Alzheimer Stages

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MUNICH, April 25, 2012 — Alzheimer-related changes in the visual cortex have been observed at the single-cell level using two-photon calcium imaging. The changes could reveal distinct stages in Alzheimer’s disease with a specific order in time. Alzheimer’s not only has devastating effects on memory and learning, but it can impair a person’s sense of smell or vision. Typically, these changes in sensory cognition show themselves behaviorally only when the disease is more advanced. Microscopic images of a brain section (bottom: overview, top: enlarged view of the visual cortex), obtained...Read full article

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    Published: April 2012
    Glossary
    photonics
    The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
    Alzheimer stagesAlzheimers diseaseArthur KonnerthBiophotonicsChristine GrienbergerCommunicationscortical circuitscortical neuronsEuropeGermanyImagingInstitute for Advanced Studyneuron degenerationneuronsphotonicsplaque-forming beta-amyloidResearch & TechnologySensors & Detectorssignaling activitysingle-neuron observationsTechnical University MunichTUMtwo-photon calcium imaging

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