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PI Physik Instrumente - Revolution In Photonics Align LW LB 3/24

Superresolution Microscopy Images Neurons on the Nanoscale

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Dr. Brian Rankin, !%Mobius Photonics%!

Recent advances allow superresolution microscopy to deliver on its promise of using focused light to provide glimpses of the inner workings of living organisms, resolving structures on the scale of tens of nanometers. The past decade witnessed a renaissance in far-field light microscopy. After initial demonstrations proved that the diffraction-limited resolution barrier could be overcome by manipulating the molecular states of fluorophores used to label the sample, superresolution approaches and methods for their implementation multiplied. The lenses of superresolution microscopes are...Read full article

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    Published: July 2012
    Glossary
    nano
    An SI prefix meaning one billionth (10-9). Nano can also be used to indicate the study of atoms, molecules and other structures and particles on the nanometer scale. Nano-optics (also referred to as nanophotonics), for example, is the study of how light and light-matter interactions behave on the nanometer scale. See nanophotonics.
    sted microscopy
    STED microscopy, or stimulated emission depletion microscopy, is a super-resolution imaging technique in fluorescence microscopy that surpasses the diffraction limit, enabling the visualization of structures at the nanoscale level. This technique was developed to overcome the limitations imposed by the diffraction of light, which traditionally hindered the resolution of optical microscopy to a few hundred nanometers. Key features and principles of STED microscopy: Super-resolution: STED...
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    Basic ScienceBiophotonicsBrian RankinC. elegansCaenorhabditis elegansfar-field light microscopyFeaturesfluorescent proteinsfluorophoresImagingMicroscopyMobius PhotonicsmousenanoneurobiologyneuronsSTED microscopystimulated emission depletionsuperresolutionsuperresolution microscopy

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