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Laser Inserts DNA into Cells with a Light Touch

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GWANGJU, South Korea, Aug. 7, 2013 — A method that uses a femtosecond laser to poke a hole in the surface of a single cell and gently tug a piece of DNA through it with optical tweezers offers greater control of gene therapy and genetic engineering. Developed in the School of Mechatronics at Gwangju Institute of Science and Technology (GIST), researchers used the optical tweezers to grab hold of and transport a plasmid-coated particle to the surface of the cell. Guided by the trapped particle, they created a tiny pore in the cell membrane using an ultrashort laser pulse. While another laser beam detected the exact location...Read full article

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    Published: August 2013
    Glossary
    optical tweezers
    Optical tweezers refer to a scientific instrument that uses the pressure of laser light to trap and manipulate microscopic objects, such as particles or biological cells, in three dimensions. This technique relies on the momentum transfer of photons from the laser beam to the trapped objects, creating a stable trapping potential. Optical tweezers are widely used in physics, biology, and nanotechnology for studying and manipulating tiny structures at the microscale and nanoscale levels. Key...
    Asia-Pacificpulsed lasersBiophotonicsDNAfemtosecond lasersgene transfectionGISTGwangju Institute of Science and TechnologyLasersMicroscopyoptical tweezersResearch & TechnologySchool of MechatronicsSouth Korea

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