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Live-Cell Imaging Evolves to Find New Niches

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Marie Freebody, Contributing Editor, [email protected]

From watching embryos as they develop to viewing neurons being manipulated in the brain, live-cell imaging continues to find new applications. Since its introduction in the 1600s, improvements in microscope technology have continually broadened the types of cells and cellular processes that can be studied. Advances in automation have made this already-simple tool faster and more capable, and time-lapse imaging reveals function and dynamics in addition to structure. Live-cell imaging has enabled us to witness incredible moments in biology in unprecedented detail. Even embryogenesis...Read full article

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    Published: November 2013
    Glossary
    brightfield
    Brightfield refers to a type of microscopy and imaging technique in which the specimen is illuminated with a white light source, and the image is observed or captured against a bright background. In a bright-field microscope, the specimen appears darker against a bright background, providing high contrast for transparent or lightly stained samples. Key characteristics of bright-field microscopy include: Illumination: In bright-field microscopy, the entire specimen is illuminated with a...
    microscope
    An instrument consisting essentially of a tube 160 mm long, with an objective lens at the distant end and an eyepiece at the near end. The objective forms a real aerial image of the object in the focal plane of the eyepiece where it is observed by the eye. The overall magnifying power is equal to the linear magnification of the objective multiplied by the magnifying power of the eyepiece. The eyepiece can be replaced by a film to photograph the primary image, or a positive or negative relay...
    stochastic optical reconstruction microscopy
    Stochastic optical reconstruction microscopy (STORM) is a super-resolution microscopy technique that enables imaging of biological specimens at resolutions beyond the diffraction limit of conventional optical microscopy. It falls under the category of single-molecule localization microscopy (SMLM) methods. STORM was first introduced in 2006 and has since become a powerful tool in biological research for visualizing fine details of cellular structures. The key principle behind STORM involves...
    structured illumination microscopy
    Structured illumination microscopy (SIM) is an advanced optical imaging technique used in microscopy to enhance the resolution of images beyond the diffraction limit imposed by traditional light microscopy. The diffraction limit is a fundamental limitation that restricts the ability to distinguish fine details in the microscopic structures. SIM achieves improved resolution through a process of illuminating the specimen with a patterned light, typically a grid or a stripe pattern. This...
    AlzheimersBiophotonicsbrightfieldconfocal imagingelectron microscopyEric BetzigFeaturesfluorescent proteinsHoward Hughes Medical InstituteLeica Microsystems GmbHlive-cell imagingMarie FreebodymicroscopeNIHNikon Instruments Inc.Parkinson’sPerkinElmerpHSebastian TilleSIMSTEDstimulated emission depletionstochastic optical reconstruction microscopySTORMstructured illumination microscopytime-lapse imagingTIRFtotal internal reflection microscopywhole-animal imagingImaging & Sensingembryogenesisfluorescence imageVytas BindokasBindokasMicroscopy Core Facilitythe University of Chicagoion concentrationmembrane voltageenzyme activity3D super resolution microscopyMoiré fringesHari ShroffUS National Institutes of HealthChristopher O’ConnellO’Connelllightsheet microscopypoint-scanning confocal systemspinning disc microscopyFlash4 sCMOS cameraUltraVIEW® VoX 3D Live Cell Imaging SystemJacob TesdorpfGated-STED

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