Mark Clymer1 and Dr. Eduardo Rosa-Molinar2,3 1Datacolor Inc., Lawrenceville, NJ 08648 USA 2Biological Imaging Group, University of Puerto Rico-Río Piedras, San Juan 3Institute of Neurobiology, University of Puerto Rico-Medical Sciences, Old San JuanEstablishing a standard could allow microscopists to verify and reproduce results. Laboratory managers and researchers generally agree that having more accuracy and consistency in color rendition could assist in achieving improved evaluation of results. However, color management has seemed so complex and elusive that many scientists and medical professionals have given up on achieving it. Transmitted-light bright-field microscope images have an enormous number of variables outside the specimen itself, all of which contribute to the creation of color in the final image. 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