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Method Lends 'True Color' to Superresolution Microscopy

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Building on earlier superresolution methods, a new microscopy technique provides nanoscale spatial information on individual molecules while also revealing their spectra. SR-STORM, or spectrally resolved stochastic optical reconstruction microscopy, could enable high-resolution imaging of multiple components and local chemical environments, such as pH variations, inside a cell. "We measure both the position and spectrum of each individual molecule, plotting its superresolved spatial position in two dimensions and coloring each molecule according to its spectral position," said Ke...Read full article

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    Published: August 2015
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    stochastic optical reconstruction microscopy
    Stochastic optical reconstruction microscopy (STORM) is a super-resolution microscopy technique that enables imaging of biological specimens at resolutions beyond the diffraction limit of conventional optical microscopy. It falls under the category of single-molecule localization microscopy (SMLM) methods. STORM was first introduced in 2006 and has since become a powerful tool in biological research for visualizing fine details of cellular structures. The key principle behind STORM involves...
    Research & TechnologysuperresolutionAmericasCaliforniaBerkeleyKe XuMicroscopyBiophotonicsSR-STORMSTORMXiaowei Zhuangstochastic optical reconstruction microscopyTech PulseBioScan

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