Search Menu
Photonics Media Photonics Marketplace Photonics Spectra BioPhotonics EuroPhotonics Vision Spectra Photonics Showcase Photonics ProdSpec Photonics Handbook

Application Note: NIR Spectroscopy Aids Diagnosis of Neonatal Brain Injury

Facebook Twitter LinkedIn Email Comments
A near-infrared (NIR) spectroscopy system has been used to measure cerebral changes and oxygen utilization in vivo, offering a noninvasive diagnostic technique for neonatal brain injury.

Researchers from University College London, the Institute for Women's Health and the neonatal unit of the University College London Hospital Trust designed and tested the system, known as CYRIL (cytochrome research instrument and application).

The CYRIL near-infrared spectroscopy system. Courtesy of Princeton Instruments.

The system used the Acton series LS-785 lens-based spectrograph and the PIXIS:512F scientific CCD camera from Princeton Instruments of Trenton, N.J. The camera's cooling technology ensured low-noise performance.

CYRIL simultaneously measured cerebral changes in tissue oxygenation and hemodynamics by estimating the changes in hemoglobin concentration. The portable system also tracked oxygen utilization by measuring the oxidation state of cytochrome-c-oxidase (CCO), which is responsible for more than 95 percent of oxygen metabolism in the body.

Acquiring quantitative NIR spectral data and systemic data at the same time, the system permitted multimodal data analysis. In a cohort of six newborn infants with neonatal encephalopathy, data indicated that the relationship between hemoglobin oxygenation changes and CCO oxidation changes during spontaneous oxygen desaturation events was significantly correlated with a magnetic resonance spectroscopy-measured biomarker of injury severity.

The research was published in Biomedical Optics Express (doi: 10.1364/BOE.5.003450).

Mar 2016
BusinesscamerasCCDResearch & Technologyapplication noteLondonEuropeEnglandUKspectroscopyPrinceton InstrumentsCYRILBiophotonicsimagingbrainNIRSpectroscopy NewsTest & Measurement

Photonics Spectra Optics Conference 2022
view all
Search more than 4000 manufacturers and suppliers of photonics products and services worldwide:

back to top
Facebook Twitter Instagram LinkedIn YouTube RSS
©2022 Photonics Media, 100 West St., Pittsfield, MA, 01201 USA, [email protected]

Photonics Media, Laurin Publishing
x Subscribe to BioPhotonics magazine - FREE!
We use cookies to improve user experience and analyze our website traffic as stated in our Privacy Policy. By using this website, you agree to the use of cookies unless you have disabled them.