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CRIMSON Project Aims to Develop Next-Gen Microscope

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Researchers this week began work on the CRIMSON project, an effort to develop advanced laser-based coherent Raman scattering microscopy. The transdisciplinary, transnational project aims to develop and introduce a tool capable of creating three-dimensional quantitative maps of subcellular compartments in living cells and organoids. The device will also enable fast-tissue classification with unprecedented biomolecular sensitivity.
The CRIMSON project aims to develop a laser-based coherent Raman scattering microscope. Courtesy of Politecnico di Milano.
The CRIMSON project aims to develop a laser-based coherent Raman scattering microscope. Courtesy of Politecnico di Milano. 

Pairing lasing techniques with artificial intelligence data analysis (with high acquisition speed) will allow device users to observe intra- and intercellular dynamic changes through time-lapse imaging.

The project has a budget of €5 million; the European Union’s Horizon 2020 research and innovation program provided funding for the project, which is slated to span 42 months. Three research centers (Politenico di Milano, Leibniz Institute of Photonic Technology, and Centre National de la Recherche Scientifique) will develop the technology. Three biomedical partners (Istituto Nazionale Tumori, Institut National de la Santé et de la Recherche Médicale, and Jena University Hospital) will validate the system on open biological questions related to cancer, as paradigmatic examples of the complexity and heterogeneity of cellular diseases.

BioPhotonics
Jan/Feb 2021
GLOSSARY
microscope
An instrument consisting essentially of a tube 160 mm long, with an objective lens at the distant end and an eyepiece at the near end. The objective forms a real aerial image of the object in the focal plane of the eyepiece where it is observed by the eye. The overall magnifying power is equal to the linear magnification of the objective multiplied by the magnifying power of the eyepiece. The eyepiece can be replaced by a film to photograph the primary image, or a positive or negative relay...
BusinessMicroscopylasersopticsimagingmicroscopeEuropeEuropean UnionEuropean Union Horizon 2020Politenico di MilanoLeibniz Institute of Photonic TechnologyCentre National de la Recherche ScientifiqueCentre National de la Recherche Scientifique (CNRS)CNRSCRIMSONRaman microscopylaser-based coherent Raman scattering microscopyBiophotonicsBioScan

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