Search Menu
Photonics Media Photonics Buyers' Guide Photonics EDU Photonics Spectra BioPhotonics EuroPhotonics Industrial Photonics Photonics Showcase Photonics ProdSpec Photonics Handbook
More News
Email Facebook Twitter Google+ LinkedIn Comments

Fast Camera Takes A New Look at Biosensing
Dec 2010
TEDDINGTON, England, Dec. 9, 2010 — A European consortium comprising the National Physical Laboratory, ST Microelectronics, the University of Edinburgh and TU Delft has been involved in the development and application of the Megaframe Imager - an ultrafast camera capable of recording images at the rate of one million frames per second.

Since the introduction of solid-state optical sensors, such as those found in digital cameras, the main trend has moved toward increasing the resolution (i.e. number of pixels) while miniaturizing the chip.

Megaframe 32 x 32 single photon avalanche diode (SPAD) array fabricated in 0.13 µm STMICRO imaging CMOS technology.

However, the other factor is the number of frames the chip is capable of recording in a given time. Until recently, fast cameras (i.e. those capturing more than the 24 fps required for 'normal' video) were only used in niche markets in science and entertainment.

Now that higher-than-video speeds are achievable, a whole new range of previously unthinkable applications have emerged – such as: cellular / sub-cellular imaging; neural imaging; biochemical sensors; DNA / protein microarray scanning; automotive collision studies; and high-sensitivity astronomical observations.

The Megaframe Imager, which uses an extremely sensitive single photon avalanche diode (SPAD) device and bespoke on-chip intelligence, has shown that it could be a powerful technology in biosensing.

The research team has demonstrated detection of viral DNA binding events using fluoresence lifetime imaging at the very low target concentrations relevant in biosensing applications with acquisition times of less than 30 seconds.

DNA microarrays are important tools for biomolecular detection. Widely used for gene expression profiling, disease screening, mutation and forensic analysis, they also hold much promise for the future development of personalized drugs and point of care testing devices.

The team’s paper, published in Biomedical Optics Express, is titled “Fluorescence lifetime biosensing with DNA microarrays and a CMOS-SPAD imager.”

This work was funded by the EU's Sixth Framework program.

For more information, visit: 

Referring to the bandwidth and spectrum location of the signal produced by television or radar scanning.
biochemical sensorsbioimagingbiomolecular detectionBiophotonicsbiosensorcamerascellular imagingCMOSDNA microarraysEuropefluorescence lifetime imagingimagesimagingMegaframe ImagerminiaturizationnanoNational Physical Laboratoryneural imagingoptical sensoropticsResearch & TechnologySensors & Detectorssingle photon avalanched diodesingle photon countingSPADST MicroelectronicsTU Delftultrafast cameraUniversity of EdinburghVideo

Terms & Conditions Privacy Policy About Us Contact Us
back to top
Facebook Twitter Instagram LinkedIn YouTube RSS
©2018 Photonics Media, 100 West St., Pittsfield, MA, 01201 USA,

Photonics Media, Laurin Publishing
x We deliver – right to your inbox. Subscribe FREE to our newsletters.
We use cookies to improve user experience and analyze our website traffic as stated in our Privacy Policy. By using this website, you agree to the use of cookies unless you have disabled them.