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3D Mapping of Neural Circuits In Vivo Opens the Window on Neurological Disease

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Modifications with SLMs to existing two-photon microscopes can provide noninvasive probes deep within the cortex.

ANNA LINNENBERGER, MEADOWLARK OPTICS INC.

Despite extensive research, brain function and neurological diseases are poorly understood. Complexities arise from the quantity of neurons in the brain and from the densely interconnected networks of intermixed cell types. Tools neuroscientists have traditionally relied upon include the patch clamp, which probes electrical activity of a single neuron, and fMRI, which images activity in volumes containing millions of neurons. These approaches target two vastly different scales. However, it is possible that the brain functions through firing patterns in neural circuits and that...Read full article

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