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Airy Beam Light-Sheet Microscopy Holds Promise for Life Sciences Imaging

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Prized for its rapid 3D imaging capability, low phototoxicity and high contrast, Airy beam light-sheet microscopy is especially well-suited for cancer biology and neuroscience.

KISHAN DHOLAKIA and JONATHAN NYLK, UNIVERSITY OF ST. ANDREWS; PETE PITRONE, GRAEME MALCOLM and ROBERT FORSTER, M SQUARED LASERS LTD.

Airy light-sheet microscopy (ALSM) has great potential to help further research and clinical diagnoses through its ability to image larger 3D volumes of tissues and organoids. Developed in the last three years, it is best-suited to the fields of regenerative medicine, cancer biology, neuroscience and developmental biology, as ALSM can acquire images, as well as 3D datasets, with higher resolution over larger fields of view (FOV) than its predecessors. Profile: Airy beam parked in the focal plane of the detection lens. Courtesy of University of St. Andrews, School of Physics and...Read full article

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