To expand the toolbox of imaging in living cells, researchers from Colorado State University and the Tokyo Institute of Technology have developed a genetically encoded, antibody-based probe that works with specificity in vivo. Probes built from antibodies were genetically fused with mature fluorophores. When loaded into cells, the probes bind and light up specific targets (epitopes) within the proteins of interest as soon as the epitopes are accessible. The probe, called the human influenza hemagglutinin (HA) frankenbody, can light up, in multiple colors, HA-tagged nuclear, cytoplasmic,...Read full articleRelated content from Photonics MediaARTICLESNIH Researchers Speed Image Processing for Fluorescence MicroscopyAdvances in image processing techniques could reduce post-processing time for highly complex microscopic images up to several thousandfold, based on work done by a research team at the National...BioPhotonics Sep/Oct 2020 IssueThree-Photon Microscopy Reveals Immune Cell Behavior in Real TimeA research group from Cornell University has used three-photon microscopy to image the full depth of the popliteal lymph node in a living mouse — reportedly for the first time. The researchers...BioPhotonics May/Jun 2022 Issue4D OCT Helps to Solve Mystery of Early Embryonic HeartbeatScientists from Stevens Institute of Technology and Baylor College of Medicine used 4D optical coherence tomography (OCT) to study the pumping mechanism underlying the developing mammalian heart. 4D...BioPhotonics Nov/Dec 2020 IssueVirginia Tech Receives $2.4M to Optically Measure Brain ActivityResearchers at the Fralin Biomedical Research Institute at Virginia Tech Carilion School of Medicine (VTCSM) received a $2.4 million National Institutes of Health grant to use optically pumped...BioPhotonics Jul/Aug 2021 IssuePRODUCTSCamera Reference Design KitThe THSCU101 Camera Reference Design Kit from Thine is a 13-MP Phase-Detection Auto-Focus (PDAF) USB Video Class (UVC) kit addressing a wide range of embedded, machine vision, and streaming camera...Vision Spectra Autumn 2021 IssueFluorescent IR DyesThe CF® 850 and CF® 870 fluorescent IR dyes from Biotium Inc. are novel long wavelength dyes with >850 nm emission maxima for life science researchers. With high brightness, aqueous...BioPhotonics Nov/Dec 2021 IssueMicroscope CameraThe LC35 microscope camera from Olympus Corp. provides quality brightfield images in a cost-effective package. With a 3.5-MP CMOS sensor and versatile exposure times and resolution modes, the...Photonics Showcase April 2022 IssueAI MicroscopeThe APEXVIEW™ APX100 All-in-One Microscope from Evident Corp. provides publication-quality images for life science research. Featuring Olympus optics, intuitive software, artificial...Photonics.com 6/20/2022PHOTONICS HANDBOOK ARTICLESAspheric Lenses: Design Considerations: This first of two articles will cover design and manufacturing options for aspheres; the second will include more detail on manufacturing and testing processes. These articles will provide the tools optics designers need to tailor their designs to the appropriate manufacturing process and to optimize the cost of component fabrication.Aspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookMicroscopy Illumination: Considering Nonlaser Light Sources: Metal halide and LED light sources are changing the illumination landscape in microscopy. Brighter, easier to use and growing in application, they are driving new options in fluorescence, conventional bright-field and other contrast techniques.As recently as five years ago, shopping for a microscope light source was fairly straightforward. 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However, the selection of...Photonics.com 6/16/2022WEBINARSThe Future of Imaging: Three PerspectivesPresenters: Professor Stephen Boppart The Future of Healthcare With Optical Biomedical Imaging A medical doctor and professor at the University of Illinois, Boppart's...Photonics.com 12/14/2011Setting Up a Simple and Cost-Efficient Two-Photon Microscope for NeuroscienceIn this webinar, Max Eisele, Ph.D., will give an introduction to two-photon microscopy and highlight the potential of multiphoton excitation as compared to the standard fluorescence microscopy...Photonics.com 10/14/2020Cellular Bioluminescence Imaging of Circadian ClocksJoin Us for a Free Webinar on Cellular Bioluminescence Imaging of Circadian Clocks With David K. Welsh, M.D. and Colin Coates Bioluminescence imaging of live cells has recently been recognized...Photonics.com 4/26/2016The Low-Noise Revolution Changes the Game … AgainDiscovery in the life sciences is moving at warp speed. 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Quinsigamond Community College and WPI received a $4M grant...Photonics.com 2/21/2018Supporting the Photonics Industry from the Laboratory - LIGHT MATTERS 01.2018On this month's episode of Light Matters, we take you to central Massachusetts as Worcester Polytechnic Institute and Quinsigamond Community College take on a comprehensive joint photonics laboratory...Photonics.com 1/18/2018Light Matters Extra: Weird and Strange: Quantum Photonics - 03.2018In this month's Light Matters Extra, we take you to the Quantum Photonics Laboratory at MIT run by Dr. Dirk Englund. Dr. Englund's group, the Quantum Photonics Group, is made up of postdocs and...Photonics.com 3/29/2018PHOTONICS BUYERS' GUIDE CATEGORIESMedical/Biomedical Light SourcesFluorescence MicroscopesPhoton Imaging DetectorsBioluminescence MicroscopesCOMPANIESLaCroix Precision OpticsOptics that Defend, Build, Cure and Discover The LaCroix name is synonymous with quality precision optics. Since 1947, three generations of family leadership have placed LaCroix Precision Optics...Photonics Buyers' GuideAvantes BVPhotonics Buyers' GuideMad City Labs Inc.Mad City Labs, Inc. is a leading manufacturer of piezo nanopositioning systems and instrumentation capable of sub-nanometer positioning resolution. Our product line of nanopositioners,...Photonics Buyers' GuideOptolong Optics Co. LtdOptolong Optics Co., Ltd is a manufacturer of fluorescence filters and astronomy filters. We also offer other interference filters such as UV filters, visible filters and near-infrared filters,...Photonics Buyers' Guide