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Broad Palette of Fluorescent Dyes May Advance Biological Imaging

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To better illuminate the inner workings of cells, researchers have developed a way to adjust the properties of fluorescent dyes deliberately, resulting in an expanded palette of dyes that are bolder, brighter and more cell-permeable. The novel technique could allow chemists to synthesize dyes in hundreds of different colors. For their work, researchers at Howard Hughes Medical Institute (HHMI) focused on rhodamines, a family of fluorescent dyes that are especially bright and cell-permeable, but somewhat limited in their color range. These are novel rhodamine dyes synthesized in...Read full article

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    Published: October 2017
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    Research & TechnologyeducationAmericasImagingLight SourcesMaterialsMicroscopysuperresolutionmedicalmedicineBiophotonicsfluorescent dyesJanelia FluorBioScan

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