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Cell-based assays become three-dimensional

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David Shenkenberg

Cell-based assays can enable pharmaceutical manufacturers to determine the efficacy and toxicity of a drug. In these assays, cells containing a fluorescent reporter molecule grow in a single two-dimensional layer. Currently, cells must be removed and counted using a fluorescence microscope, a time-consuming process. Using a plate reader would be rapid and convenient, but the fluorescence intensity is too weak and contains too much noise from reporter molecules that are released from dead cells. Shang-Tian Yang and colleagues at Ohio State University in Columbus have developed a device...Read full article

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