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Computational Imaging Tools Improve Lateral OCT Resolution

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A new technique called optical coherence refraction tomography (OCRT) is able to increase the resolution of OCT down to a single micrometer in all directions, even in a living patient. Because OCT provides better depth resolution than lateral direction, it has traditionally worked best when the tissue being imaged contains mostly flat layers. To extend the power of OCT for live imaging of tissues throughout the body, researchers at Duke University needed to overcome the trade-off between lateral resolution and depth of imaging. The researchers, led by professor Joseph Izatt, combined...Read full article

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    Published: August 2019
    Glossary
    optical coherence tomography
    Optical coherence tomography (OCT) is a non-invasive imaging technique used in medical and scientific fields to capture high-resolution, cross-sectional images of biological tissues. It provides detailed, real-time, and three-dimensional visualization of tissue structures at the micrometer scale. OCT is particularly valuable in ophthalmology, cardiology, dermatology, and various other medical specialties. Here are the key features and components of optical coherence tomography: Principle of...
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    ophthalmology
    Ophthalmology is a branch of medicine that focuses on the anatomy, physiology, and diseases of the eyes and visual system. Ophthalmologists are medical doctors who specialize in the diagnosis, treatment, and prevention of eye disorders and diseases. They are trained to provide comprehensive eye care, including medical, surgical, and optical interventions. Key areas within ophthalmology include: General eye care: Ophthalmologists perform routine eye examinations to assess visual acuity,...
    machine learning
    Machine learning (ML) is a subset of artificial intelligence (AI) that focuses on the development of algorithms and statistical models that enable computers to improve their performance on a specific task through experience or training. Instead of being explicitly programmed to perform a task, a machine learning system learns from data and examples. The primary goal of machine learning is to develop models that can generalize patterns from data and make predictions or decisions without being...
    Research & TechnologyeducationAmericasDuke UniversityJoseph IzattImagingOpticsLight Sourcesoptical coherence tomographyoptical coherence refraction tomographysuperresolutionoptical imagingBiophotonicsophthalmologymedicalmachine learningcomputational imagingBioScan

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