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Dye Boosts Bioimaging Capability

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DOUGLAS FARMER, SENIOR EDITOR
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NOTRE DAME, Ind., June 15, 2020 — Fluorescence imaging has been a boon to research and medicine because of its ability to examine affected areas noninvasively. But the dyes used for these purposes have their disadvantages, and as resolution needs have grown stronger, the stakes for accuracy have increased exponentially. A tumor-burdened mouse, imaged with the aid of s775z dye. Courtesy of Cynthia Schreiber. A group of scientists from the University of Notre Dame has found that by creating a stable dye with a molecular shield — amounting to “arms” that prevent undesired binding with other dyes —...Read full article

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    Published: June 2020
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    Research & Technologyfluorescent imagingfluorescence imagingImagingNotre DameUniversity of Notre Damebioimagingfluorescent dyesingle-moleculesuperresolutionsuperresolution imagingBiophotonics

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