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FACS assay detects DNA damage

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Assay can identify specific types of damage, probably in various organisms

David L. Shenkenberg

Jeanine M. Pennington and Susan M. Rosenberg from Baylor College of Medicine in Houston have developed a fluorescence-activated cell sorting (FACS) assay that detects DNA damage. They used the assay to study breaks that occur naturally in both strands during replication. These breaks can occur when the replication machinery encounters obstacles and no longer can continue the process. Rejoining the broken strands sometimes results in chromosomal rearrangements likely to cause cancer and other genetic diseases, although sometimes these rearrangements can result in beneficial genetic changes...Read full article

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    Published: August 2007
    BiophotonicsDNAfluorescence-activated cell sorting (FACS) assayResearch & TechnologySensors & Detectors

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