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Fluorescence Detection Gains in Sensitivity

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Surface-plasmon-coupled emission shows promise to expand its chemical and biological sensing applications.

Dr. Chris D. Geddes, Dr. Ignacy Gryczynski, Dr. Joanna Malicka, Dr. Zygmunt Gryczynski and Dr. Joseph R. Lakowicz, University of Maryland

The biotechnology and medical diagnostics industries could soon benefit from a technique that promises enhanced sensitivity over conventional fluorescence detection methods. Developed at the University of Maryland in Baltimore and called directional surface-plasmon-coupled emission, it shows promise for applications such as DNA hybridization, high-throughput screening for drug discovery, single-molecule detection, immunoassay and bioassay development, protein analysis and emerging nanophotonics technologies. Surface plasmons are basically electron oscillations on the surface of metals —...Read full article

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    Published: February 2004
    Basic ScienceBiophotonicsbiotechnologdirectional surface-plasmon-coupled emissionFeaturesfluorescence detectionmedical diagnosticsUniversity of Maryland

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