Genetically encoded fluorescent sensors are providing a way to track the mobilization of labile heme (LH) in cells. The sensors offer significant insight into the nature and dynamics of this potentially dangerous nutrient of which there has been little understanding until now. Although ratiometric fluorescent techniques for monitoring cell activity have been in use for a while, this is the first known technique that specifically senses heme. The heme sensors can be used across multiple organisms, including E. coli, yeast and human cell lines. Osiris Martinez-Guzman and Bindu...Read full articleRelated content from Photonics MediaARTICLESMicrofluidic Device with Fluorescent Sensor Detects EbolaA faculty-researcher at Rochester Institute of Technology (RIT) has developed a prototype microdevice with biosensors that can detect the Ebola virus. The microfluidic device is an automated chip...BioPhotonics Jul/Aug 2019 IssueAntibody-based Probe Developed for Live-Cell Imaging in VivoTo expand the toolbox of imaging in living cells, researchers from Colorado State University and the Tokyo Institute of Technology have developed a genetically encoded, antibody-based probe that...BioPhotonics September 2019 IssueSpectroscopic Toolkit for Structural Biology Could Aid in Drug DesignA fluorescence-based imaging technique for monitoring single molecules could lead to a better understanding of how molecules are assembled, function, and interact, aiding in structure-guided drug...BioPhotonics May/Jun 2020 Issue‘Firefly’ Imaging Technique Sheds Light on Molecular ForcesUsing tools made of luminescent DNA, researchers at Emory University have visualized the mechanical forces of cells at the molecular level. The researchers demonstrated the technique on human blood...BioPhotonics Nov/Dec 2020 IssuePRODUCTSHyperspectral SensorThe Hyperspec® Solar Induced Fluorescence (SIF) imaging sensor from Analytik is designed for remote sensing, particularly plant and crop photosynthesis and climatology applications where...Photonics.com 4/21/2021CMOS Image SensorsThe XGS 9400 and the XGS 8000 global shutter CMOS image sensors from ON Semiconductor Corp. have been announced by Framos Technologies Inc. The sensors provide resolutions of 9.4 and 8.8 MP...Photonics Spectra December 2019 IssueMedical Image Signal ProcessorsThe OH0120 and OH0130 ASIC-based boards from OmniVision Technologies Inc. are part of the OVMed medical image signal processor line, designed to pair with high-performance medical image sensors for...BioPhotonics Jan/Feb 2021 IssueCell Imaging ReaderThe Cytation™ 7 Cell Imaging Multi-Mode Reader from BioTek Instruments Inc. combines an automated upright microscope, an inverted microscope, and multi-mode microplate detection in a single...BioPhotonics Mar/Apr 2020 IssuePHOTONICS HANDBOOK ARTICLESFluorescence Lifetime Imaging: Choosing the Best Approach: Fluorescence lifetime imaging microscopy (FLIM), which measures the spatial distribution of the fluorescence decay, can be achieved either in the time or in the frequency domain. Each approach exhibits advantages and disadvantages, depending on the type of light detector and acquisition method employed.The term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...Photonics HandbookAspheric Lenses: Design Considerations: This first of two articles will cover design and manufacturing options for aspheres; the second will include more detail on manufacturing and testing processes. These articles will provide the tools optics designers need to tailor their designs to the appropriate manufacturing process and to optimize the cost of component fabrication.Aspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookDetectors: Guideposts on the Road to Selection: Choosing a detector requires evaluating many operating parameters and desired outcomes. This introduction provides a series of guideposts that will help lead the way to the right one.Any number of medical, industrial and analytical applications requires the detection of light. Chemiluminescence, bioluminescence, fluorescence and atomic absorption are just a few, and all require a...Photonics HandbookLaser Measurement Systems: Best Practices: When purchasing a laser, learning how to apply, troubleshoot, and evaluate that device is very important.Given the pace at which technology advances, there always seems to be a learning curve. With the abundance of consumer electronics available, there typically is no right or wrong way to use these...Photonics HandbookWHITEPAPERSCamera-based Products - Benefits of an ISO13485:2016-Certified SupplierWhat advantages does a supplier certified according to the medical device standard ISO 13485:2016 offer to a manufacturer of camera-based medical products? Our White Paper describes the requirements...Photonics.com 4/22/2019Fluorescence Microscopy Technique Provides New Views of Biological ProcessesIntroduction to the technique of MicroMirror TIRF (total internal reflection fluorescence) microscopy. The MicroMirror TIRF microscopy technique offers significant signal-to-noise ratio improvements...Photonics.com 10/1/20193 Lasers IN-ONE – FISBA READYBeam™ in Life SciencesThe FISBA READYBeam™ easily integrates into your set-up or instrument. Light-sheet Fluorescence Microscopy or Selective Plane Illumination (SPIM) enables high resolution imaging of large biological...Photonics.com 6/12/20203 Lasers-IN-ONE – Discover the FISBA READYBeam™!The development of diode emitters towards increasing power and variety, facilitated their usage in a rapidly growing field of scientific and industrial applications. In various cases it becomes...Photonics.com 6/12/2020WEBINARSFrom Product to Profit: The Powerful Impact of Early-stage, User-Based ResearchAdditional Q&A - Q: How can I distribute my questionnaire? If I am in the early stage of designing a specific product for India and I know my target audience... How can I reach them? Do you...Photonics.com 7/30/2014Radiometric Accuracy and Commercial UAVs: A Clash of Cultures?While the explosion in the commercial drone industry has benefited a wide variety of applications including crop mapping and farmland surveying, the delivery to the farmer of accurate radiometric...Photonics.com 7/7/2020Biophotonic Imaging for Medicine: A Digital ConferenceResearchers from around the world presented their latest work at “Biophotonic Imaging for Medicine: A Digital Conference.” Presentations focused on a range of light-based imaging and...Photonics.com 6/11/2015Setting Up a Simple and Cost-Efficient Two-Photon Microscope for NeuroscienceIn this webinar, Max Eisele, Ph.D., will give an introduction to two-photon microscopy and highlight the potential of multiphoton excitation as compared to the standard fluorescence microscopy...Photonics.com 10/14/2020PHOTONICS DICTIONARY TERMSimage intensifierAn electro-optic device consisting of an electronic tube equipped with a light-sensitive electron emitter at one end, and a phosphor screen at the other end, used to convert low levels of light at...EDU.photonics.com 11/19/2012epifluorescence microscopyFluorescence imaging technique in which the excitation light from the objective is directed into the sample producing emission at all angles. Light emitted into the objective is measured allowing the...EDU.photonics.com 3/5/2018single-walled carbon nanotubesReferred to as SWCNTs, these cylindrical nanostructures composed of a folded sheet of graphene can be used as near-infrared markers for small animal multiplex imaging. Emitting at different...EDU.photonics.com 11/14/2016Light Sheet Fluorescence Microscopy (LSFM)Also known as single plane illumination microscopy (SPIM), this process was designed for imaging of sensitive samples and fast biological processes in vivo. In this method, a light sheet illuminates...EDU.photonics.com 3/5/2018MEDIAiSpectrophotometer & Spray-On Lens - LIGHT MATTERS 05.29.2013-Spray-on Lens -iSpectrophotometer -Polariton Laser This week on Light Matters: a spray-on flat lens works in the ultraviolet, a smartphone camera becomes a high-resolution spectrophotometer, and a...Photonics.com 5/29/2013Light Tomorrow with TodayLuminate NY, the only optics, photonics and imaging (OPI) accelerator and investment fund in the world, announced the final winners at the Light Tomorrow with Today event in Rochester, NY. For the...Photonics.com 7/2/2018Photonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 2/21/2018PIC Fundamentals, Design at Heart of AIM Photonics Summer AcademyStudents from large and small size companies and bigger Department of Defense affiliates of the AIM Photonics Institute took part in the recent AIM Photonics Summer Academy at MIT. This was the third...Photonics.com 7/30/2018PHOTONICS BUYERS' GUIDE CATEGORIESFluorescence MicroscopesFluorescence Imaging SystemsFluorescent Light SourcesA fluorescent light source is a tube containing mercury vapor and lined with a phosphor. When current is passed through the vapor the strong ultraviolet emission excites the phosphor, which emits...Photomultiplier Tube DetectorsCOMPANIESart photonics GmbHWith more than 20 years of experience in design, development, and manufacturing of specialty optical fibers and complex optical fiber assemblies, art photonics GmbH is a major solution provider in...Photonics Buyers' GuideEdinburgh Instruments Ltd.Founded in 1971, Edinburgh Instruments Ltd. is a global provider of sophisticated, state-of-the-art analytical instrumentation for optical spectroscopy. We design and manufacture a range of...Photonics Buyers' GuideWasatch Photonics Inc.At Wasatch Photonics, we’re fascinated by the many ways light can be used to understand nature and solve the problems that touch our lives each day, and it shows in our innovation, applications...Photonics Buyers' GuideDiffraction LimitedDiffraction Limited is known for global leadership in Scientific Imaging Solutions. For 27 years, people like you in science, industry, biology, pharmacology, physics, engineering, and astronomy...Photonics Buyers' Guide