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Fluorescent Probe Identifies Cancer Stem Cells in the Body

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A fluorescent probe, called AlDeSense, has demonstrated the ability to find and track cancer stem cells (CSCs) in cultures of multiple human cancer cell lines as well as in live mice. The new probe is a small molecule that binds to an enzyme (ALDH1A1) that is related to the property of stemness in cancer cells. The probe becomes activated and emits a fluorescent signal only when it reacts with the target enzyme, which CSCs produce in high concentrations. Researchers at the University of Illinois at Urbana-Champaign, who developed the probe, targeted an enzyme that was experimentally...Read full article

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