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Fluorescent Sensor Detects Drug-Induced Protein Stress in Cells

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A fluorescent sensor that will become activated in a cell when misfolded proteins in the cell begin to aggregate could be an effective way to detect drug-induced proteome stress prior to cell death. Researchers from Penn State University have designed an unstable protein, called AgHalo, to sense proteome stress through the protein’s aggregation. AgHalo was tagged with a fluorogenic ligand that fluoresced when AgHalo formed soluble aggregates. When the AgHalo protein began to misfold and aggregate, the dye interacted with the hydrophobic portions of the protein and began to...Read full article

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