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Fluorogenic Method Detects Two-Protein Aggregation in Live Cells

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A new method uses fluorescence to detect potentially disease-causing forms of proteins as they misfold and unravel due to stress or mutations. Researchers from Pennsylvania State University (Penn State) and the University of Washington re-engineered a fluorescent compound and developed a method by which two different proteins can fluoresce at the same time as they misfold and aggregate inside a living cell, highlighting forms that could play a role in several neurodegenerative diseases, including Alzheimer’s and Parkinson’s. The new AggTag method allows researchers to see...Read full article

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