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Rocky Mountain Instruments - Infrared Optics LB

Hydrogen replacement improves fluorescent dyes’ detection, stability and shelf life

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Charles T. Troy, [email protected]

Investigators have increased the shelf life and detection ability of fluorescent probes that are necessary for studying a variety of inflammatory diseases, including cancer and atherosclerosis, by trading one specific hydrogen atom for an isotope that is twice as heavy. The probes detect and measure reactive oxygen species, which play a role in disease processes. “By replacing a hydrogen atom with a deuterium atom during the synthesis of several fluorescent probes, we increased the stability and shelf life of the dyes and also improved their ability to detect smaller concentrations...Read full article

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    Published: October 2010
    amine oxidation reactionatherosclerosisBasic Sciencebiomedical imagingBiophotonicsBioScancancercardiologycellsCharles T. TroyConcert PharmaceuticalsdeuteriumDHEdihydroethidiumdyesEmory Universityfluorescent dyesfluorescent probesGeorgia TechH-Cy7hydocyanineshydrogen atomhydrogen replacementImagingin vivoinflammatory diseaseisotopeskinetic isotopeKousik KunduNational Institutes of HealthNational Science FoundationNewsNiren MurthyOpticsoxidationoxidizedoxygen speciesprobesradical oxidant probesreactive oxygen speciesSarah Knightstandard fluorescent probeW. Robert Taylor

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