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Internal Reflection-Based Microscopy Images Single Protein

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PHOENIX, May 5, 2022 — A team from Arizona State University (ASU) has introduced evanescent scattering microscopy (ESM), a label-free method for sensitive imaging of biomolecules, including proteins. The single-molecule microscopy technique is based on total internal reflection (TIR), an optical phenomenon that occurs when light passes from a high-refractive medium, like glass, into a low-refractive medium, like water. ESM could allow researchers to visualize proteins and other biomolecules with more clarity and by simpler means than existing microscopy methods. TIR occurs when waves arriving at the...Read full article

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