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Hamamatsu Corp. - Earth Innovations LB 2/24

Lens-Free Fluorescence Microscope to Achieve High Throughput, Resolution

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JOEL WILLIAMS, ASSOCIATE EDITOR
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A fluorescence microscope being developed by imec researchers will be able to achieve high throughput and high resolution, without a lens component. The technology could significantly speed up next-generation DNA sequencing and cellular research, as well as enable studies on larger scales. Part of the trouble that researchers face with ordinary fluorescence microscopes, said Niels Verellen, principal scientist at imec, stems from certain limitations of lenses. As magnification increases, throughput — or field of view — decreases. The light field's interference patterns...Read full article

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    Published: July 2021
    Glossary
    fluorescence
    Fluorescence is a type of luminescence, which is the emission of light by a substance that has absorbed light or other electromagnetic radiation. Specifically, fluorescence involves the absorption of light at one wavelength and the subsequent re-emission of light at a longer wavelength. The emitted light occurs almost instantaneously and ceases when the excitation light source is removed. Key characteristics of fluorescence include: Excitation and emission wavelengths: Fluorescent materials...
    fluorescence microscopy
    Fluorescence microscopy is a specialized optical imaging technique used in biology, chemistry, and materials science to visualize and study specimens that exhibit fluorescence. Fluorescence is the phenomenon where a substance absorbs light at one wavelength and emits light at a longer wavelength. In fluorescence microscopy, fluorescent dyes or proteins are used to label specific structures or molecules within a sample. The basic principles of fluorescence microscopy involve illuminating the...
    chip
    1. A localized fracture at the end of a cleaved optical fiber or on a glass surface. 2. An integrated circuit.
    integrated photonics
    Integrated photonics is a field of study and technology that involves the integration of optical components, such as lasers, modulators, detectors, and waveguides, on a single chip or substrate. The goal of integrated photonics is to miniaturize and consolidate optical elements in a manner similar to the integration of electronic components on a microchip in traditional integrated circuits. Key aspects of integrated photonics include: Miniaturization: Integrated photonics aims to reduce the...
    light field
    The term light field refers to the spatial distribution of light rays traveling in all directions through a given space. It includes information about the intensity and direction of light rays at every point in a scene. In the context of imaging and photography, the light field is a comprehensive description of the light entering a camera or other optical system. Key points about light field include: Directional information: Unlike traditional photographs that capture only the total light...
    Research & TechnologyMicroscopyfluorescencefluorescence microscopychipintegrated photonicsphotonic chipSensors & DetectorsCMOSImaginglens-freeBiophotonicsIMECEuropeNiels Verellenlight fieldmathematicsmathematical modelprime number factorizationTech PulseBioScan

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