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Making the Connection: Optics, Neural Activity and Behavior

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Fiber photometry and fluorescence microscopy bolster optogenetic research into how the brain works.

An international army of neuroscientists is trying to better understand the inner workings of the brain by exploring the correlations between neural activity and behavior of freely moving or partially restrained lab animals. The best method for neural activity control, activation or silencing of opsin-expressing neurons is optogenetics. The prevalent optics-based methods for monitoring the neural activity of fluorophore-labeled neurons are fiber photometry and head-mounted fluorescence microscopy. Neuroscientists appear equally divided over whether fiber photometry or fluorescence...Read full article

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