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Methodology Aids Microscopic Study of Fibrils in Molecules

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DOUGLAS FARMER, SENIOR EDITOR
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Researchers from Washington University in St. Louis have found a mechanism to efficiently and accurately measure the point spread functions (PSFs) of the position of molecules, called variance upper bound (VUB). They believe this will someday aid scientists and clinicians as they look to understand what is happening at the molecular level in the body. The researchers specifically used fluorescent molecules to bind with amyloid fibers and measure their differences in structure. As it turns out, in so doing, they found a way to bypass typical limitations associated with single-molecule...Read full article

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    Published: July 2020
    Glossary
    fluorescence microscopy
    Fluorescence microscopy is a specialized optical imaging technique used in biology, chemistry, and materials science to visualize and study specimens that exhibit fluorescence. Fluorescence is the phenomenon where a substance absorbs light at one wavelength and emits light at a longer wavelength. In fluorescence microscopy, fluorescent dyes or proteins are used to label specific structures or molecules within a sample. The basic principles of fluorescence microscopy involve illuminating the...
    Research & TechnologyMicroscopyfluorescence microscopysingle-moleculesingle-molecule localization microscopysingle-molecule localizationSMLMsingle-molecule orientation localization microscopySMOLMTech PulseBioScan

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