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Microscopy Methods Combined to Achieve Molecular Resolution

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An international team of researchers has combined superresolution microscopy method dSTORM with expansion microscopy to overcome a previous limitation of superresolution microscopy. Previously, nanometer resolution had only been a theoretical possibility. Antibodies carrying a fluorescent dye to label cell structures could not reach their intended target. (a) Three-dimensional Ex-dSTORM of 3.2× expanded centrioles; measuring bar 1 µm. (b) The enlarged section of (a) shows the ninefold symmetry of the percentile; measuring bar 500 nm. (c) Three-dimensional Ex-dSTORM of...Read full article

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    Published: July 2020
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    fluorescence
    Fluorescence is a type of luminescence, which is the emission of light by a substance that has absorbed light or other electromagnetic radiation. Specifically, fluorescence involves the absorption of light at one wavelength and the subsequent re-emission of light at a longer wavelength. The emitted light occurs almost instantaneously and ceases when the excitation light source is removed. Key characteristics of fluorescence include: Excitation and emission wavelengths: Fluorescent materials...
    Research & TechnologyMicroscopyuniversity of wurzburgsuperresolutionsuper-resolutionsuper-resolution microscopydSTORMdSTORM imagingexpansion microscopymolecular imagingfluorescencefluorescence agentsuperresolution microscopyBioScan

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