Scientists at University of Erlangen-Nuremberg (FAU) have engineered an automated, high-precision biomechatronics system into a multiphoton microscope. The system allows isometric calcium ion (Ca2+)-graded force (or passive viscoelasticity measurements) and second-harmonic generation (SHG) recordings to be made simultaneously. Using this MechaMorph system, the researchers studied force and SHG in single extensor digitorum longus (EDL) muscle fibers from mice. The system accurately measured muscle weakness caused by structural changes in muscle tissue at the same time the muscular architecture...Read full articleRelated content from Photonics MediaARTICLESMultiphoton Microscopy Reveals Lattice Network of Skin FibersUsing multiphoton microscopy (MPM), researchers at Kyoto University showed that the collagen fibers in the skin are arranged in a mesh-like lattice and not in a clear geometric orientation as...BioPhotonics October 2019 IssueIntravital Imaging Provides Insight into Liver Disease ProgressionThe high-resolution, 3D-viewing capabilities provided by a new microscopy method from the Korea Advanced Institute of Science and Technology (KAIST) could lead to insights into nonalcoholic fatty...BioPhotonics Nov/Dec 2020 IssueNIH Researchers Speed Image Processing for Fluorescence MicroscopyAdvances in image processing techniques could reduce post-processing time for highly complex microscopic images up to several thousandfold, based on work done by a research team at the National...BioPhotonics Sep/Oct 2020 IssueResearchers Combine OCT and 3D Microscopy to Image EmbryosTo help researchers and clinicians better understand the cellular-level events that occur during embryonic development, a team from the University of Houston and Baylor College of Medicine is...BioPhotonics Jul/Aug 2019 IssuePRODUCTSDigital MicroscopeThe Visioner 1 digital microscope from ZEISS enables all-in-one focus in real time with a Micro-mirror Array Lens System (MALS™). With its extended depth of field, manufacturing users in...Photonics.com 2/18/2021OCT VCSELThe Caliper-HERO vertical-cavity surface-emitting laser (VCSEL) from Octlight ApS is a scalable solution for 3D optical coherent tomography (OCT) imaging. With single-mode wavelength tuning,...Photonics.com 4/5/20211P/2P Super-Res TIRF DichroicAs multiphoton microscopy has increasingly become the norm within the microscopy community, the need to combine multiphoton and single-photon excitation has risen as a necessity for many emerging...Promoted Content May 2019 IssueBlack MicroplatesBlack microplates from Porvair Sciences Ltd. are available in 48-, 96-, and 384-well formats, minimizing sample degradation by exposure to light, even over long storage periods. Precisely...Photonics.com 1/20/2020PHOTONICS HANDBOOK ARTICLESAspheric Lenses: Design Considerations: This first of two articles will cover design and manufacturing options for aspheres; the second will include more detail on manufacturing and testing processes. These articles will provide the tools optics designers need to tailor their designs to the appropriate manufacturing process and to optimize the cost of component fabrication.Aspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookMeasuring Surface Roughness: The Benefits of Laser Confocal Microscopy: 3D imaging and ultrahigh resolution are ideal for the inspection of materials with defined surface finishes and textures.When evaluating the surface of a component, surface roughness can be assessed by eye or by rubbing it with a fingertip. Common expressions include “shiny,” “lusterless and...Photonics HandbookFluorescence Lifetime Imaging: Choosing the Best Approach: Fluorescence lifetime imaging microscopy (FLIM), which measures the spatial distribution of the fluorescence decay, can be achieved either in the time or in the frequency domain. Each approach exhibits advantages and disadvantages, depending on the type of light detector and acquisition method employed.The term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...Photonics HandbookWhat Is Photonics?Photonics is the study of light and other types of radiant energy whose quantum unit is the photon. 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With the FV3000 microscope, researchers at the Keio University...Photonics.com 10/3/2019Are Large Image Sensors A Perfect Fit for Large Field of View Microscope Applications?In the last years nearly all microscope manufacturers used image circles with 18 mm diameter to image their field of view to cameras connected to their microscopes. Only recently some microscope...Photonics.com 12/2/2019WEBINARSBiophotonic Imaging for Medicine: A Digital ConferenceResearchers from around the world presented their latest work at “Biophotonic Imaging for Medicine: A Digital Conference.” Presentations focused on a range of light-based imaging and...Photonics.com 6/11/2015Innovation Along the Value Chain: Creating Optics for Metrology ApplicationsToday, process innovation is as important as product innovation to the creation of a competitive product. The entire value chain, from the definition of the specifications based on the needs of the...Photonics.com 4/29/2020The Future of Imaging: Three PerspectivesPresenters: Professor Stephen Boppart The Future of Healthcare With Optical Biomedical Imaging A medical doctor and professor at the University of Illinois, Boppart's...Photonics.com 12/14/2011Setting Up a Simple and Cost-Efficient Two-Photon Microscope for NeuroscienceIn this webinar, Max Eisele, Ph.D., will give an introduction to two-photon microscopy and highlight the potential of multiphoton excitation as compared to the standard fluorescence microscopy...Photonics.com 10/14/2020PHOTONICS DICTIONARY TERMSvisual fault locatorA device that enables visual tracing of a fiber optic cable to check for breaks and defects by coupling visible light into the cable. Also called fiber tracer.EDU.photonics.com 9/8/2009random access multiphoton microscopyAlso known as RAMP microscopy, random access multiphoton microscopy is a microscopic technique that uses multiple acousto-optic modulators to enable faster and addressable scanning of 3D cellular...EDU.photonics.com 3/5/2018tissue opticsThe study of the optical properties of living tissue. Increased understanding of the behavior of light in this varied, turbid medium, especially its scattering and absorption characteristics, is...EDU.photonics.com 9/8/2009Light Sheet Fluorescence Microscopy (LSFM)Also known as single plane illumination microscopy (SPIM), this process was designed for imaging of sensitive samples and fast biological processes in vivo. 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For the...Photonics.com 7/2/2018Supporting the Photonics Industry from the Laboratory - LIGHT MATTERS 01.2018On this month's episode of Light Matters, we take you to central Massachusetts as Worcester Polytechnic Institute and Quinsigamond Community College take on a comprehensive joint photonics laboratory...Photonics.com 1/18/2018Light Matters Extra: Taking Photonics Innovations from the Lab to the Operating Room - 01.2018In this month's Light Matters Extra, we give you an in-depth look at the relationship between researchers and scientists at the University of California Davis, and surgeons and clinicians at nearby...Photonics.com 1/18/2018PHOTONICS BUYERS' GUIDE CATEGORIESFiber Optic Cable Path and Fault Locating EquipmentOptical Testing InstrumentsNeurosurgery Laser SystemsMedical Laser Delivery SystemsCOMPANIESLaCroix Precision OpticsOptics that Defend, Build, Cure and Discover The LaCroix name is synonymous with quality precision optics. Since 1947, three generations of family leadership have placed LaCroix Precision Optics...Photonics Buyers' GuideFOCtek Photonics Inc.FOCtek provides customers with all types of custom manufactured lenses, Precision Optical Components, Polarizing Optics, Prisms, Filters, Coatings, Optical Systems, Crystals, Nonlinear Crystals,...Photonics Buyers' GuideOhara Corporation, Western OfficeOhara manufactures precision optical glasses: strip/slab, cut/molded blanks, pressings, high homogeneity blanks, fine gobs, polished ball lenses, near-UV transmitting i-Line glass, ceramic...Photonics Buyers' GuideA.R.W. Optical CorporationARW Optical is your reliable manufacturer of quality optics and coatings. Beamsplitters • Prototyping through volume-production quantities • High-performance and durable optical...Photonics Buyers' Guide