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Muscle Weakness Measured with Multiphoton Imaging

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Scientists at University of Erlangen-Nuremberg (FAU) have engineered an automated, high-precision biomechatronics system into a multiphoton microscope. The system allows isometric calcium ion (Ca2+)-graded force (or passive viscoelasticity measurements) and second-harmonic generation (SHG) recordings to be made simultaneously. Using this MechaMorph system, the researchers studied force and SHG in single extensor digitorum longus (EDL) muscle fibers from mice. The system accurately measured muscle weakness caused by structural changes in muscle tissue at the same time the muscular architecture...Read full article

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