Scientists at University of Erlangen-Nuremberg (FAU) have engineered an automated, high-precision biomechatronics system into a multiphoton microscope. The system allows isometric calcium ion (Ca2+)-graded force (or passive viscoelasticity measurements) and second-harmonic generation (SHG) recordings to be made simultaneously. Using this MechaMorph system, the researchers studied force and SHG in single extensor digitorum longus (EDL) muscle fibers from mice. The system accurately measured muscle weakness caused by structural changes in muscle tissue at the same time the muscular architecture...Read full articleRelated content from Photonics MediaARTICLESThree-Photon Microscopy Reveals Immune Cell Behavior in Real TimeA research group from Cornell University has used three-photon microscopy to image the full depth of the popliteal lymph node in a living mouse — reportedly for the first time. The researchers...BioPhotonics May/Jun 2022 IssueIntravital Imaging Provides Insight into Liver Disease ProgressionThe high-resolution, 3D-viewing capabilities provided by a new microscopy method from the Korea Advanced Institute of Science and Technology (KAIST) could lead to insights into nonalcoholic fatty...BioPhotonics Nov/Dec 2020 IssueNIH Researchers Speed Image Processing for Fluorescence MicroscopyAdvances in image processing techniques could reduce post-processing time for highly complex microscopic images up to several thousandfold, based on work done by a research team at the National...BioPhotonics Sep/Oct 2020 IssueHybrid Microscopy Method, AI Deliver Robust Images in SecondsScientists at the European Molecular Biology Laboratory (EMBL) combined AI algorithms with light-field microscopy and light-sheet microscopy. The hybrid, AI-enhanced approach shortened the time...BioPhotonics Jul/Aug 2021 IssuePRODUCTSOptical Parametric OscillatorThe 17OPO-1-50 S Optical Parametric Oscillator from AMS Technologies AG generates short laser pulses for applications in the field of photoacoustic imaging. The devices are based on nonlinear...Photonics Spectra July 2022 IssueFemtosecond Laser SourcesThe CRONUS-2P and CRONUS-3P microscopy-dedicated femtosecond laser sources from Light Conversion covers applications in functional neuroimaging, optogenetics, and deep imaging. CRONUS-3P...BioPhotonics May/Jun 2022 IssueAutomated Cell CounterThe CytoSMART Exact FL automated cell counter from CytoSMART Technologies is a dual fluorescence device with an expanded field of view and high performance. The system features an advanced...BioPhotonics Jul/Aug 2021 IssueLaser IlluminatorsThe FLTT series of high-power laser illuminators from Frankfurt Laser Co. is based on high-quality VCSEL chips and an optical design. With an optical output power of up to 25 W, it is possible...Photonics Spectra November 2021 IssuePHOTONICS HANDBOOK ARTICLESAspheric Lenses: Design Considerations: This first of two articles will cover design and manufacturing options for aspheres; the second will include more detail on manufacturing and testing processes. These articles will provide the tools optics designers need to tailor their designs to the appropriate manufacturing process and to optimize the cost of component fabrication.Aspheric surfaces are powerful tools that combine the optical corrections of multiple lenses into a single element (Figure 1) and affect performance in ways that spherical optics cannot. For example,...Photonics HandbookMeasuring Surface Roughness: The Benefits of Laser Confocal Microscopy: 3D imaging and ultrahigh resolution are ideal for the inspection of materials with defined surface finishes and textures.When evaluating the surface of a component, surface roughness can be assessed by eye or by rubbing it with a fingertip. Common expressions include “shiny,” “lusterless and...Photonics HandbookFluorescence Lifetime Imaging: Choosing the Best Approach: Fluorescence lifetime imaging microscopy (FLIM), which measures the spatial distribution of the fluorescence decay, can be achieved either in the time or in the frequency domain. Each approach exhibits advantages and disadvantages, depending on the type of light detector and acquisition method employed.The term fluorescence is often applied as a synonym for photoluminescence, although luminescence actually covers fluorescence and phosphorescence. Both of these terms describe the process of...Photonics HandbookWhat Is Photonics?: An overview and brief history of photonics technology and its applicationsPhotonics is the study of light and other types of radiant energy whose quantum unit is the photon. The impact of photonics on research, technology, navigation, culture, astronomy, forensics, and...Photonics HandbookWHITEPAPERSHigh-resolution deep brain imaging up to a depth of 1.4 mm using White Dwarf OPCPAA new microscopy technique developed at EMBL in Heidelberg enables highest imaging resolution for in vivo neuronal activity measurements deep in the brain, driven by a Class 5 Photonics White Dwarf...Photonics.com 12/7/2021Advantages of Measuring Surface Roughness with White Light InterferometryThis application note discusses the use of mean roughness measurements with white light interferometry (WLI) optical profilers. Spatial filters are explained, as well as some of the normative...Photonics.com 8/1/20203 Questions to Ask Before Buying Infrared InterferometryImportant considerations in obtaining infrared optical metrology, for measuring transmitted wavefront error, optical quality, and surface quality. The paper asks questions to help guide the reader in...Photonics.com 6/1/2022A Novel Measurement System to Aid Polished Optical Surface Manufacturing When Working with Coated SurfacesTopography becomes more important in quality assurance for manufacturing. This regards the characterization of macro-sized to medium optics and the optimization of a manufacturing process using a...Photonics.com 11/3/2020WEBINARSBiophotonic Imaging for Medicine: A Digital ConferenceResearchers from around the world presented their latest work at “Biophotonic Imaging for Medicine: A Digital Conference.” Presentations focused on a range of light-based imaging and...Photonics.com 6/11/2015European Photonics Manufacturing Services Funded by ECThis event is supported by the European initiatives presented and is moderated by EPIC, the European Photonics Industry Consortium. The European Commission is helping companies access the...Photonics.com 6/30/2021Innovation Along the Value Chain: Creating Optics for Metrology ApplicationsToday, process innovation is as important as product innovation to the creation of a competitive product. The entire value chain, from the definition of the specifications based on the needs of the...Photonics.com 4/29/2020The Future of Imaging: Three PerspectivesPresenters: Professor Stephen Boppart The Future of Healthcare With Optical Biomedical Imaging A medical doctor and professor at the University of Illinois, Boppart's...Photonics.com 12/14/2011PHOTONICS DICTIONARY TERMSrandom access multiphoton microscopyAlso known as RAMP microscopy, random access multiphoton microscopy is a microscopic technique that uses multiple acousto-optic modulators to enable faster and addressable scanning of 3D cellular...EDU.photonics.com 3/5/2018visual fault locatorA device that enables visual tracing of a fiber optic cable to check for breaks and defects by coupling visible light into the cable. Also called fiber tracer.EDU.photonics.com 9/8/2009tissue opticsThe study of the optical properties of living tissue. Increased understanding of the behavior of light in this varied, turbid medium, especially its scattering and absorption characteristics, is...EDU.photonics.com 9/8/2009Light Sheet Fluorescence Microscopy (LSFM)Also known as single plane illumination microscopy (SPIM), this process was designed for imaging of sensitive samples and fast biological processes in vivo. In this method, a light sheet illuminates...EDU.photonics.com 3/5/2018MEDIAPhotonics on the Showroom Floor and in the Lab - LIGHT MATTERS 02.2018On this month's episode of Light Matters, we take you on a brief tour of the Higgins Laboratories at Worcester Polytechnic Institute (WPI). Quinsigamond Community College and WPI received a $4M grant...Photonics.com 2/21/2018Supporting the Photonics Industry from the Laboratory - LIGHT MATTERS 01.2018On this month's episode of Light Matters, we take you to central Massachusetts as Worcester Polytechnic Institute and Quinsigamond Community College take on a comprehensive joint photonics laboratory...Photonics.com 1/18/2018Light Tomorrow with TodayLuminate NY, the only optics, photonics and imaging (OPI) accelerator and investment fund in the world, announced the final winners at the Light Tomorrow with Today event in Rochester, NY. For the...Photonics.com 7/2/2018Light Matters Extra: Taking Photonics Innovations from the Lab to the Operating Room - 01.2018In this month's Light Matters Extra, we give you an in-depth look at the relationship between researchers and scientists at the University of California Davis, and surgeons and clinicians at nearby...Photonics.com 1/18/2018PHOTONICS BUYERS' GUIDE CATEGORIESFiber Optic Cable Path and Fault Locating EquipmentOptical Testing InstrumentsNeurosurgery Laser SystemsFiber LasersA fiber laser is a laser in which the lasing medium is an optical fiber doped with low levels of rare-earth halides to make it capable of amplifying light. Output is tunable over a broad range and...COMPANIESLaCroix Precision OpticsOptics that Defend, Build, Cure and Discover The LaCroix name is synonymous with quality precision optics. Since 1947, three generations of family leadership have placed LaCroix Precision Optics...Photonics Buyers' GuideOptikos CorporationThe Optical Engineering Experts® Optikos designs and manufactures metrology products for measuring and assuring optical image quality; and provides optical engineering design, development,...Photonics Buyers' GuideFOCtek Photonics Inc.FOCtek provides customers with all types of custom manufactured lenses, Precision Optical Components, Polarizing Optics, Prisms, Filters, Coatings, Optical Systems, Crystals, Nonlinear Crystals,...Photonics Buyers' GuideOZ Optics LimitedEstablished in 1985, OZ Optics is a leading worldwide supplier of fiber optic components, test equipment and sensors. OZ Optics manufactures its products in three locations, Ottawa (Canada),...Photonics Buyers' Guide