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Nanoscope’s 3D Superresolution Reveals Alzheimer’s Source

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A superresolution nanoscope could enable 3D imaging of amyloid plaques — a characteristic feature of Alzheimer’s disease — with up to 10 times greater detail than conventional microscopes. Researchers at Purdue University combined active shaping of point spread functions and adaptive optics to enable robust 3D single-molecule switching nanoscopy (SMSN) imaging within tissues. They used the technology to image through 30-μm-thick brain sections in a mouse model of Alzheimer’s disease. They were able to visualize and reconstruct the morphology and the nanoscale...Read full article

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