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OPSLs — Unique Benefits Driving Growth in the Life Sciences

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Optically pumped semiconductor laser (OPSL) technology dominates some of the leading applications for continuous wave (CW) and modulatable laser light, including those used for cytometry, sequencing, fluorescence microscopy and ophthalmological photocoagulation. OPSLs have rapidly transitioned from next-generation CW laser technology status to a dominant force within the life sciences. With more than 100,000 systems operating in the field, OPSL’s unique combination of advantages have made them highly successful tools.

DR. MATTHIAS SCHULZE, COHERENT INC.

In an OPSL, laser diodes are used to pump a thin semiconductor chip, thus enabling an incredible level of design flexibility in terms of power and wavelength scalability. The quantum well structure of the gain chip determines the OPSL’s output wavelength, which can be set anywhere along a wide range of the near-infrared spectrum. Efficient intracavity doubling (or tripling) then converts this to either a visible or UV output wavelength. As a result, an OPSL can fill in the wavelength gaps from the spectrum produced by laser diode modules. OPSLs and laser diodes often are...Read full article

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    Published: October 2015
    Glossary
    superresolution
    Superresolution refers to the enhancement or improvement of the spatial resolution beyond the conventional limits imposed by the diffraction of light. In the context of imaging, it is a set of techniques and algorithms that aim to achieve higher resolution images than what is traditionally possible using standard imaging systems. In conventional optical microscopy, the resolution is limited by the diffraction of light, a phenomenon described by Ernst Abbe's diffraction limit. This limit sets a...
    fluorescence microscopy
    Fluorescence microscopy is a specialized optical imaging technique used in biology, chemistry, and materials science to visualize and study specimens that exhibit fluorescence. Fluorescence is the phenomenon where a substance absorbs light at one wavelength and emits light at a longer wavelength. In fluorescence microscopy, fluorescent dyes or proteins are used to label specific structures or molecules within a sample. The basic principles of fluorescence microscopy involve illuminating the...
    continuous wave lasersDPSS lasersFeaturessuperresolutionLEDsBiophotonicsLasersMicroscopyImagingLight SourcesAmericasOPSLsoptically pumped semiconductor laserCW laser lightmodulatable laser lightflow cytometersfluorescence microscopyophthalmological coagulationlaser diodeshigh-thoughput sequencingproduct miniaturizationbiofuel researchCoherentmassive parallelismNGSnext-generation sequencingThermo Fisher ScientificPacific Biosciencesstochastic microscopy imagingconfocal microscopySTORMRESOLFTdSTORMFPALMCaliforniaMatthias Schulze

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