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Optogenetic Tool Controls Voltage-Gated Calcium Channels

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An optogenetic tool has been developed for controlling voltage-gated calcium (CaV) channels to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. The tool, called optoRGK, provides a way to interrogate the physiological and pathophysiological processes that are mediated by CaV channels. Voltage-gated Ca2+ channels (CaV) are important therapeutic targets for cardiovascular and neuropsychiatric disorders. Researchers engineered a class of genetically encoded photoswitchable inhibitors for CaV channels to control Ca2+ signals (yellow graphs in round...Read full article

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