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Optogenetic Tool Controls Voltage-Gated Calcium Channels

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An optogenetic tool has been developed for controlling voltage-gated calcium (CaV) channels to enable photo-tunable modulation of CaV channel activity in excitable mammalian cells. The tool, called optoRGK, provides a way to interrogate the physiological and pathophysiological processes that are mediated by CaV channels. Voltage-gated Ca2+ channels (CaV) are important therapeutic targets for cardiovascular and neuropsychiatric disorders. Researchers engineered a class of genetically encoded photoswitchable inhibitors for CaV channels to control Ca2+ signals (yellow graphs in round...Read full article

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    Published: May 2018
    Glossary
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    Research & TechnologyeducationAmericasAsia-PacificoptogeneticsLight SourcesmedicalmedicineBiophotonicscalcium signalingcardiovascular diseasecalcium channelsBioScan

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