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Optogenetics Platform Uses Light to Activate Control of Intracellular Phase Transitions

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A novel optogenetics platform, dubbed optoDroplet, uses light to activate phase transitions inside living cells. The optoDroplet system is being used to study the condensed phases driven by intrinsically disordered protein regions (IDRs). Its use could lead to a better understanding of cellular processes, including how proteins assemble and the potential link between protein aggregates and disease. Researchers at Princeton University used the optoDroplet system to induce phase transitions in cells driven by the IDRs of various ribonucleoproteins (RNPs), including FUS, DDX4 and HNRNPA1....Read full article

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