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Pain Relief May Join Growing List of Optogenetics Applications

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Optogenetics may someday provide doctors with a noninvasive, highly focused way to treat chronic pain. By making the cells responsible for pain transmission sensitive to light, the technique may be able to target, desensitize and reduce bioelectric activity in these cells. To demonstrate the potential role of optogenetics in pain management, researchers at McGill University bred a transgenic mouse model with a light-sensitive trait in the Nav1.8+ nociceptors, i.e., the peripheral neurons that are known to transmit pain. The terminals of the peripheral nociceptors were silenced...Read full article

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    Published: April 2016
    Glossary
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    photosensitivity
    That property of a material indicating that it will react when exposed to light energy.
    photonics
    The technology of generating and harnessing light and other forms of radiant energy whose quantum unit is the photon. The science includes light emission, transmission, deflection, amplification and detection by optical components and instruments, lasers and other light sources, fiber optics, electro-optical instrumentation, related hardware and electronics, and sophisticated systems. The range of applications of photonics extends from energy generation to detection to communications and...
    Research & TechnologyAmericasMcgilloptogeneticslight therapyphotosensitivityOpticsphotonicspain managementBiophotonicsCanadaopsinopiateTech Pulse

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