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Organic Optogenetics Tool Shines Light on Brain Communication

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Light-sensing proteins called rhodopsins are used in optogenetics to control neuronal activity, but existing rhodopsins can have low efficacy, especially when they are used to control synaptic activity between neurons. A mosquito-derived rhodopsin discovered by scientists at the Weizmann Institute of Science provides precise, spatiotemporal control of synaptic activity in the brain. Its use as an optogenetics tool could further scientists’ understanding of the functional roles of specific neuronal pathways. The research team, which is led by professor Ofer Yizhar, uses optogenetic...Read full article

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    Published: May 2021
    Glossary
    optogenetics
    A discipline that combines optics and genetics to enable the use of light to stimulate and control cells in living tissue, typically neurons, which have been genetically modified to respond to light. Only the cells that have been modified to include light-sensitive proteins will be under control of the light. The ability to selectively target cells gives researchers precise control. Using light to control the excitation, inhibition and signaling pathways of specific cells or groups of...
    Research & TechnologyeducationEuropeWeizmann Institute of ScienceoptogeneticsLight SourcesSensors & DetectorsOpticsBiophotonicsmedicalneuronallight-sensing proteinsrhodopsinsneurotransmittersbrain activitymosquito rhodopsinbio-inspired opticsBioScan

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